Transformation of the Triclabendazole Substance upon Mechanochemical Processing

The use of mechanochemical processing, particularly the mechanochemical modification of poorly soluble medicinal substances, such as anthelmintics, significantly improves their water solubility and bioavailability, which enhances their parasiticidal activity and broadens their spectrum of action. For the synthesis of these drugs, it is important to study the chemical stability of starting substances both during their mechanochemical transformations and during storage of the resulting products. This work continues research on the chemical stability of benzimidazole substances, in particular, triclabendazole, which possesses high activity against larvae and adult F. hepatica, a dangerous helminth in humans and animals.