P062 | Interim results of the questionnaire on predisposition to acute lymphoblastic leukemia in the AIEOP-BFM ALL 2017 protocol
Abstract
About 8–10% of pediatric cancers are associated with pathogenic variants in cancer predisposition genes. In acute lymphoblastic leukemia (ALL), suspicion of predisposition arises from a family history of early-onset tumors, prior malignancies, comorbidities, or known genetic syndromes.Children enrolled in the AIEOP-BFM ALL 2017 protocol completed a short questionnaire (Diagnosis Form 2) to identify clinical features suggestive of cancer predisposition.Among 1,415 patients, 208 (14.7%) met at least one criterion for suspected predisposition. Of these, 64 (31%) had a family history of early-onset cancer (
Fields of Study & Subjects
Acute Lymphoblastic Leukemia research
BRCA gene mutations in cancer
Multiple and Secondary Primary Cancers
Publication details
- Journal / source
- Haematologica
- Volume
- 111
- Issue
- s1
- Publication date
- 3 March 2026
- Language
- EN