Anti-aging Properties of Curcuma mangga Val. Powder in Skin Aging Wistar Rats Induced by D-galactose

Skin aging is characterized by the appearance of wrinkles, dull skin, and decreased skin elasticity. White turmeric (Curcuma mangga Val.) is a natural antioxidant containing curcuminoids and polyphenols that can fight free radicals and help rejuvenate the skin. This study aims to evaluate the potential of white turmeric as an anti-aging agent in Wistar rats induced with D-galactose. The treatment was carried out for 3 weeks on 5 groups of rats, namely: control (standard feed), negative control (D-galactose induction with aquabidest), two treatment groups with D-galactose induction and white turmeric doses of 27 mg/200 g and 81 mg/200 g BW, and positive control (D-galactose induction and vitamin E). The results showed that administration of white turmeric at a dose of 81 mg/200 g BW had a significant effect on increasing antioxidant activity, as indicated by increased SOD (81.43%) and VEGF levels (28.47 pg/mL), decreased MDA levels (2.22 nmol/mL), MMP-1 level (9.77 ng/mL), and blood glucoses level (87.42 mg/dL) as well as better histopathological observations of skin tissue compared to the D-galactose-induced model group without treatment. Thus, white turmeric shows potential as an anti-aging agent in Wistar rats induced to age using D-galactose.