Effectiveness of Artemisia pallens against behavioral depression and impact on monoaminergic and GABAergic systems
Abstract
Depression is characterized by decreased monoamine levels (dopamine, noradrenaline, serotonin), gamma-aminobutyric acid (GABA), elevated corticosterone, and dysregulation of the hypothalamic-pituitary-adrenal axis. This study aims to examine the effects of Artemisia pallens against behavioral depression in mice using the tail suspension test. Mice were divided into several groups and received different concentrations of ethyl acetate fractions of A. pallens. The duration of immobility of mice, brain levels of monoamines, GABA, and plasma corticosterone concentration were estimated. Extract (400 mg/kg) significantly (p
Fields of Study & Subjects
Medicinal Plant Extracts Effects
Medicinal Plants and Bioactive Compounds
Medicinal Plants and Neuroprotection
Publication details
- Journal / source
- Bangladesh Journal of Pharmacology
- Volume
- 21
- Issue
- 1
- Pages
- 28–34
- Publication date
- 2 March 2026
- Language
- EN