Association of high sensitivity C-reactive protein with chronic kidney disease in type 2 diabetes mellitus patients

Background: Chronic kidney disease represents a serious health problem which can lead to progressive loss of kidney function and eventually to end-stage renal disease. In many studies high sensitivity C-reactive protein (hsCRP) has been found as a sensitive marker of low-grade systemic inflammation. Recent studies suggest that patients with CKD suffer from inflammation which deteriorate progressively with increasing levels of renal failure. Objective: To evaluate the association of high sensitivity C-reactive protein with CKD in type 2 diabetes mellitus patients. Methods: A cross sectional study consists of total 153 study subjects were selected from the outpatient department of BIRDEM general hospital. Study subjects were divided into 3 groups, Group-I type 2 DM patients, group-II type 2 DM patients with CKD stage 1-3, group-III type 2 DM patients with CKD stage-4. Results: The mean± SD level of serum hsCRP in group-I, group-II and group-III were 4.44±11.08, 9.89±10.20 and 12.27±12.70 respectively. The results were significantly higher in group-III which is highly significant (P