Comparative Analysis of Serum IgE and Eosinophil Levels in Patients with Asthma and Allergic Conjunctivitis

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Authors: Mohammed Asaduzzaman Khan, Mohammad Shafiqul Islam, Mohammad Shafiqul Islam, Farhana Akter, Md Shahen
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Abstract

Background: Asthma and allergic conjunctivitis are closely related to allergic disorders driven by IgE-mediated and eosinophil-associated inflammation. Both conditions share common immunological pathways involving Th2 cytokines and hypersensitivity to environmental allergens. Measuring serum IgE and eosinophil levels provides valuable insight into the severity and type ofallergic response. Comparative evaluation of these biomarkers helps to clarify their relationship and diagnostic significance in asthma and allergic conjunctivitis patients.Objectives: This study aimed to compare serum IgE and eosinophil levels between asthma and allergic conjunctivitis patients, and correlate these biomarkers with clinical parameters.Method and Materials: This prospective study included 134 adults with asthma or AC. Data on demographics and clinical history were collected via questionnaire. Serum IgE (ELISA) and eosinophil counts (automated analyzer) were measured. Statistical analysis used independent t-tests and chi-squaretests to compare the groups, with p

Fields of Study & Subjects

Asthma and respiratory diseases Allergic Rhinitis and Sensitization Dermatology and Skin Diseases

Publication details

Journal / source
Journal of Dhaka National Medical College & Hospital
Volume
31
Issue
2
Pages
34–39
Publication date
15 January 2026
Language
EN