Association of systemic inflammatory biomarkers with the clinical forms of acute cholecystitis

Introduction: The objective of this study was to conduct a comparative evaluation of systemic inflammatory markers in various forms of gallbladder inflammation in patients with acute calculous cholecystitis (ACC). Methods: The article presents information about a scientific study conducted to study the content of peripheral blood leukocytes, taking into account the form of ACC in 116 patients. The patients were divided into two groups: Group I consisted of 53 patients with the catarrhal form of ACC, and Group II included 63 patients with the destructive forms (phlegmonous and gangrenous). Dynamic studies conducted before and after cholecystectomy in 116 patients showed that the level of leukocytes depended on the form of ACC. Results: The cell indices evaluated in this study, such as lymphocyte neutrophil ratio (LNR), lymphocyte monocyte ratio (LMR), neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and systemic inflammation response index (SIRI), present a more accessible and efficient alternative to assess systemic inflammation in clinical practice, especially in the context of acute cholecystitis. Conclusion: Systemic inflammatory cell biomarkers, such as the LNR, LMR, NLR, MLR, LER , and SIRI, are significantly associated with the clinical forms of ACC and provide useful insights into the intensity of the inflammatory process in the gallbladder.