Antioxidant mediated hepato-renal protection by Punica granatum peel extract in fipronil-treated rats

The present study was carried out to check the ameliorative effect of pomegranate peel extract (PPE) against fipronil-induced hepato-renal toxicity in male Wistar albino rats. A study was conducted for 45 days period in 4 groups of male Wistar albino rats with 6 animals in each group. Group I and III served as vehicle (distilled water) control and Punica granatum control. Group II animals were treated with fipronil @ 10 mg/kg b. wt. orally with distilled water. Group IV animals were treated with both fipronil and pomegranate peel extract @ 10 and 200 mg/kg b. wt. respectively for a period of 45 days using distilled water as a vehicle. Tissue pieces of liver and kidney were subjected for oxidative stress estimation, which revealed a significant increase (P