Effect of isoprenaline on precontracted isolated pulmonary artery of goat

International Journal of Advanced Biochemistry Research 2026 Open access

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Authors: S Ilavarasan, Meemansha Sharma, Mamta Meena, Anand Mohan Mishra, Pravin Maruti Madabhavi, Manju Gari, Shweta Singh, Riya Talariya, Anshuk Sharma, V. A. Aneesha, Madhu Cholenahalli Lingaraju, Subhashree Parida
+1 more Thakur Uttam Singh
DOI: 10.33545/26174693.2026.v10.i1f.6988
Cited by: 0

Abstract

The objective of the present study was to investigate the effect of isoprenaline on goat precontracted isolated pulmonary artery. Isoprenaline (10⁻⁹-10⁻³ M) elicited a concentration-dependent relaxation in histamine (10 µM) precontracted pulmonary arterial rings of goat with a maximal relaxation of 21.31±3.72% (n=6) and a pD2 of 7.82±0.24. Mechanical removal of the endothelium did not significantly modify the relaxant response with maximal relaxation. Pretreatment with propranolol (10 µM) attenuated the isoprenaline-mediated relaxation. Blockade of KATP channels with glibenclamide (10 µM) significantly (p

Fields of Study & Subjects

Pulmonary Hypertension Research and Treatments Cardiovascular Neuropeptides and Oxidative Stress Research Receptor Mechanisms and Signaling

Publication details

Journal / source
International Journal of Advanced Biochemistry Research
Volume
10
Issue
1
Pages
471–475
Publication date
1 January 2026