Effectiveness of smoking on ACE-2, IL-6 levels in men

Smoking is a significant risk factor for various cardiovascular and respiratory diseases, impacting key biomarkers such as Angiotensin-Converting Enzyme 2 (ACE-2) and Interleukin-6 (IL-6). ACE-2 is crucial for regulating blood pressure and cardiovascular health, while IL-6 is a cytokine involved in inflammatory responses. Recent research indicates that smoking disrupts the renin-angiotensin system, potentially lowering ACE-2 levels and exacerbating systemic inflammation. This study aimed to investigate the relationship between smoking and these biomarkers, shedding light on the underlying pathophysiological processes and informing targeted interventions for smokers at risk of inflammatory and cardiovascular diseases. The study involved 100 participants, including 50 smokers and 50 healthy controls, with significant differences observed in physiological and biochemical parameters such as systolic blood pressure, hemoglobin, packed cell volume, ACE-2, and IL-6 levels. Results showed that smokers had higher systolic blood pressure, hemoglobin, and PCV, alongside elevated ACE-2 and IL-6 levels, indicating chronic inflammation and cardiovascular risk. Furthermore, positive correlations were found between smoking frequency and duration with these health parameters, emphasizing the detrimental effects of smoking on overall health. These findings underscore the urgent need for smoking cessation programs to mitigate the associated health risks.