Comparative evaluation of anaesthetic effect of ketamine-guaifenesin and ketamine-midazolam as induction with isoflurane maintenance anaesthesia in buffaloes

The present study was undertaken to investigate the anaesthetic effect of ketamine-guaifenesin and ketamine-midazolam as induction with isoflurane maintenance anaesthesia in 12 Buffaloes. In group I, ketamine (2 mg/kg, IV) and guaifenesin (50 mg/kg, IV) and while in group II, ketamine (2 mg/kg, IV) and midazolam (0.05 mg/kg, IV) for induction of anaesthesia. The intubated Buffaloes were connected to the large animal anaesthesia machine and isoflurane in 100% oxygen. The groups were compared for anaesthetic parameters. Ketamine-guaifenesin was better induction agents in comparison to ketamine-midazolam along with isoflurane anaesthesia. Ketamine-guaifenesin-isoflurane produced effective surgical anaesthesia and found to be safe, as cardio-pulmonary functions were well preserved during maintenance anaesthesia with no deleterious effect on vital organ functions in Buffaloes.