Supercritical fluid chromatography in pharmaceutical analysis: A comprehensive review
Abstract
Supercritical fluid chromatography is an advanced analytical technique that combines aspects of liquid and gas chromatography to provide high efficiency, rapid analysis, and reduced solvent consumption. This review covers the fundamentals, apparatus, operational parameters, and method development strategies of supercritical fluid chromatography. Highlighted are its uses in the analysis of pharmaceutical compounds, including chiral drug substances, impurities, and degradation products. By outlining its advantages, disadvantages, and potential applications, this method's increasing significance in pharmaceutical quality control and regulatory compliance is illustrated.
Fields of Study & Subjects
Analytical Chemistry and Chromatography
Analytical Methods in Pharmaceuticals
Phase Equilibria and Thermodynamics
Publication details
- Journal / source
- International Journal of Pharmacy and Pharmaceutical Science
- Volume
- 8
- Issue
- 2
- Pages
- 18–25
- Publication date
- 1 February 2026
- Language
- EN