TMAO Induced Kidney Aging by Activating ZBP1-Mediated Necroptosis

Physiological Research 2026 Open access

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Authors: Q Chen, Z Qiu, Y Zhao, L Bai, Y Chen, S Jin, F Ma, J Dai
DOI: 10.33549/physiolres.935612
Cited by: 0
References: 32

Abstract

The present study was aimed to investigate whether trimethylamine-N-oxide (TMAO) contributed to kidney aging by activating necroptosis. Male C57BL/6J mice were randomly divided into Control group (3 months old) and Old group (18 months old), compared to 3-month-old controls, 18-month-old male C57BL/6J mice showed significant increases in plasma creatinine (Cre) and blood urea nitrogen (BUN) (P

Fields of Study & Subjects

Acute Kidney Injury Research Chronic Kidney Disease and Diabetes Genetics Aging and Longevity in Model Organisms

Publication details

Journal / source
Physiological Research
Volume
75
Issue
1
Pages
89–89
Publication date
10 March 2026
Language
EN