Incidence of anogenital warts in conditions of vaccination against papillomavirus infection in St. Petersburg

The incidence of anogenital warts is one of the manifestations of the human papillomavirus (HPV) infection and an early indicator of the effectiveness of vaccination. Objective: t o study the incidence of anogenital warts in conditions of vaccination against papillomavirus infection in megapolis. Materials and methods. The analysis includes data on reported cases of anogenital warts in St. Petersburg in 2005–2024. The incidence of anogenital warts among contacts of patients includes the results of examinations of 7921 individuals. Vaccination data includes on 47067 HPV vaccinated individuals in 2008–2024. The effectiveness of vaccination in dermatovenereological patients is assessed using the results of monitoring the incidence of anogenital warts among vaccinated and unvaccinated (74 individuals) in 2024–2025. Research methods: epidemiological, clinical, and statistical. Results. The incidence of anogenital warts in St. Petersburg was higher than in the Russian Federation. The incidence among women was 1,3–1,7 times higher than among men. Among contacts, anogenital warts were detected in 21,3–49,9 % of cases. A decrease in the incidence of anogenital warts among 15–17 years old girls was noted in 2024, which may be related to HPV vaccination. No new cases and recurrences of anogenital warts among vaccinated individuals during 1, 3, 6, 9 months of monitoring. Among unvaccinated individuals who received similar treatment, recurrences were observed in 25 % of cases (10/40) 1 month after treatment. Conclusion. Despite low HPV vaccination coverage and the preferential immunization of women, a statistically significant reduction in the incidence of anogenital warts was observed at the population level among female 15–17 years old adolescents. No recurrence of anogenital warts was observed in vaccinated individuals during a 9-month research period. The study results support the need inclusion of patients with dermatovenereological diseases and contacts of these individuals in immunization cohorts for epidemiological indications.