Therapeutic potential of fulvic acid in the complex treatment of oral lichen planus

The aim of this study was to evaluate the efficacy of a fulvic acid-based gel in the complex treatment of the erosive-atrophic form of oral lichen planus (OLP) in 20 patients (12 women and 8 men, mean age 45–57 years). The comprehensive therapy included professional hygiene, oral sanitation, general medication therapy, and topical application of the fulvic acid gel for 21 days. Assessment was performed clinically, using a periodontal probe and autofluorescence stomatoscopy (AFS), and by investigating oxidative stress markers (malondialdehyde, catalase) in the oral fluid. The results showed complete epithelialization of erosions in 92% of patients by day 28, a significant reduction in the inflammation area according to AFS data, and a significant normalization of biochemical parameters, indicating a reduction in oxidative stress and the high therapeutic efficacy of the studied gel.