Node-crossing vectors (“NXV”) feasibly extends Mann Whitney U to handle ties and small samples for clinical rating scales

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Authors: Keith S. Reid
Cited by: 0
References: 11

Abstract

The Mann-Whitney U test (“MWU”) is a canonical test of order used to compare two groups. A longstanding gap is that MWU handles ties and small samples incorrectly. In the present author's clinical field, this impairs analyses of ward incident counts, or “small” rating scales used for comparing clinical populations such as Clinical Global Impression (“CGI”) and Brøset Violence Checklist (“BVC”). This paper introduces Node-Crossing Vectors (“NXV”), an extension of MWU that solves those problems. While MWU uses sample size and U -scores of order to calculate probability, NXV furthermore proceeds from first principles to handle expectations of ties combinatorially. MWU is briefly outlined in NXV's terms, then proven to be inexact for small clinical rating scales. Hitherto, ties were sometimes ignored due to computational difficulty. No settled method had been extant. Here, NXV was applied a priori to real CGI scores in a real n = 13 problem which featured seven tied elements. Ties were decisive: the population parameter λ (expected τ tied elements per individual sample of size n ) critically affects power. NXV with a grounded expectation of seven tied elements gives p λ7 = 0.0280(3 sf ), above two-tailed α = 0.025, suggesting no difference. Alternatively expecting six tied elements gives p λ6 = 0.0241(3 sf ), changing the result. NXV is more exact than MWU, has viable code, and improves the analysis of two small samples. The explanation is visually accessible, and simulation data are shown. NXV arose during analyses aiming to protect the rights of restrained persons with protected characteristics and other small samples, but it is generalizable.

Fields of Study & Subjects

Probability and Statistical Research Statistical Methods in Clinical Trials Probabilistic Statistics in Medicine

Publication details

Journal / source
Frontiers in Applied Mathematics and Statistics
Volume
11
Publication date
12 January 2026
Language
EN