Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration

Frontiers in Bioengineering and Biotechnology 2026 Open access

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Authors: Yaping Liu, Xiaoxiao Wang, Xingyue Tao, Haokun Zhang, Bingyan Liu, Y. Li, Hang Wang, Huo-Min Luo, Hui-Lin Lv, Peifeng Li
DOI: 10.3389/fbioe.2025.1731605
Cited by: 2
References: 100

Abstract

This review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration. The Notch signaling pathway exerts a profound impact on cardiac health and disease progression by finely regulating the fate determination of cardiac progenitor cells, cardiac morphogenesis, and the proliferation and apoptosis of cardiomyocytes. The article also explores the research progress of the Notch signaling pathway as a potential therapeutic target and looks forward to future research directions.

Fields of Study & Subjects

Congenital heart defects research Developmental Biology and Gene Regulation Cardiac Fibrosis and Remodeling

Publication details

Journal / source
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Volume
13
Pages
1731605–1731605
Publication date
4 March 2026
Language
EN