PMMA-based composite bone cements with zirconium oxide fillers of different granulations: structural optimization and biofunctional potential
Abstract
Introduction Polymethyl methacrylate (PMMA) bone cements are widely used in orthopaedics, but their limited fatigue resistance, brittleness and lack of biological bonding to bone motivate the search for composite formulations with improved mechanical performance and biofunctional potential. Zirconium oxide (ZrO 2 ) is an attractive radiopaque ceramic filler that may reinforce the PMMA matrix while enabling microstructural optimisation. Methods Commercial Refobacin Plus acrylic bone cement containing 0.6 g gentamicin was modified with ZrO 2 particles of three granulations: nanoparticles (
Fields of Study & Subjects
Orthopaedic implants and arthroplasty
Bone Tissue Engineering Materials
Total Knee Arthroplasty Outcomes
Publication details
- Journal / source
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Volume
- 14
- Pages
- 1796706–1796706
- Publication date
- 13 May 2026
- Language
- EN