Analysis of factors influencing latent tuberculosis infection screening using QuantiFERON-TB Gold In-Tube in people living with HIV/AIDS

Objective To investigate the influencing factors associated with the risk of latent tuberculosis infection (LTBI) among people living with HIV/AIDS (PLWHA). Methods A cross-sectional study was conducted from July 2023 to July 2024, recruiting PLWHA from Wuxi City and Yangzhou City, Jiangsu Province, China. Data were collected through on-site questionnaire surveys and review of patient disease management records. QuantiFERON-TB Gold In-Tube (QFT) was used to detect LTBI. Multivariate logistic regression analysis was performed to identify factors associated with LTBI among PLWHA. Restricted cubic splines (RCS) models were employed to analyze the dose-response relationships between CD4 + cell count, CD8 + cell count, and CD4/CD8 ratio with LTBI risk. Results A total of 1184 PLWHA were enrolled, with 8.4% having concomitant LTBI. Multivariate logistic regression revealed that age group 45-