Risk factors for invasive Klebsiella pneumoniae liver abscess syndrome: a meta-analysis

Objectives: liver abscess syndrome (IKPLAS) is a life-endangering condition. This meta-analysis sought to identify factors that could potentially serve as risk factors for IKPLAS. Methods: Eight databases were retrieved. The Newcastle-Ottawa Scale and AHRQ criteria were utilized to assess the studies for quality. Stata software was used for pooling the effect size odds ratio (OR) and for subgroup analysis, sensitivity analysis, and regression analysis. Publication bias was examined leveraging funnel plots and Egger's test. Results: A total of 18 studies (cross-sectional, cohort, case-control studies) were included, with 3,133 patients. The meta-analysis revealed that the following factors were linked to a significantly elevated risk of IKPLAS: history of smoking or alcohol consumption (OR = 1.61, 95% CI: 1.05, 2.45, p = 0.028), diabetes (OR = 1.93, 95% CI: 1.49, 2.51, p