Mechanism and application of Akkermansia muciniphila in inflammatory diseases
Abstract
Chronic inflammatory diseases, closely linked to gut microbiota dysbiosis, pose a major global health burden. Akkermansia muciniphila ( A. muciniphila ), a key gut commensal, sustains immune homeostasis and metabolic balance, emerging as a promising next-generation probiotic. This review synthesizes current evidence on the mechanisms such as regulating the intestinal barrier, immunomodulation, mediating anti-inflammatory metabolites and regulating microbiota and therapeutic potential of A. muciniphila in inflammation-related diseases. Integrating these with experimental/clinical data across inflammation-related disorders establishes a coherent framework. Beyond live bacteria, advances in pasteurized formulations and bioactive derivatives highlight complementary advantages.
Fields of Study & Subjects
Gut microbiota and health
Probiotics and Fermented Foods
Infant Nutrition and Health
Publication details
- Journal / source
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Volume
- 16
- Pages
- 1819005–1819005
- Publication date
- 22 May 2026
- Language
- EN