No improvement in clinical outcomes: a propensity score analysis of inappropriate carbapenem use in children with susceptible Escherichia coli bloodstream infections
Abstract
Objective: ) bloodstream infection (BSI) using propensity score matching (PSM). Methods: BSI. This study evaluated the appropriateness of empirical antibiotic therapy (initiated before blood culture results), retrospectively judged by subsequent susceptibility testing. Patients were categorized into a standard-therapy group (n=123) and an inappropriate carbapenem therapy group (n=83). One-to-one PSM generated 67 matched pairs with balanced baseline characteristics. Standard logistic regression was adopted for correlation analyses before matching, while conditional logistic regression was used to explore risk associations with mortality, sepsis and septic shock after matching. Results: After PSM, all covariates were balanced (standardized mean differences
Fields of Study & Subjects
Antibiotic Resistance in Bacteria
Antibiotics Pharmacokinetics and Efficacy
Sepsis Diagnosis and Treatment
Publication details
- Journal / source
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Volume
- 16
- Pages
- 1829667–1829667
- Publication date
- 2 June 2026
- Language
- EN