Correlation between healthy sleep score and risk of cardia-cerebrovascular disease among people with type 2 diabetes: a prospective cohort study

Background: In the general population, healthy sleep pattern is associated with lower risk of cardia-cerebrovascular diseases (CVD). However, despite a high prevalence of sleep disorders in people type 2 diabetes(T2D), no study has investigated the relationship between sleep patterns and the risk of CVD events in this particular subpopulation. Methods: We included 6,363 participants with T2D but free of prevalent CVD at baseline from Kailuan study, a HSS(range 0-5) combining five sleep patterns (sleep duration, snoring, insomnia, early sleep-wake patterns, and excessive daytime sleepiness) was calculated. Cox regression models were used to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) of incident CVD. Results: During a median follow-up of 5.80 years, 790 participants developed first CVD event (12.42%). In multivariate Cox analysis, the risk of CVD decreased by 11% (HR, 0.89; 95% CI 0.83-0.96) per one-point increment in the HSS. Compared to those with a sleep score of 0-1, participants with a score of 4 and 5 had a 26%(HR, 0.73; 95% CI 0.55-0.99) and 43%(HR, 0.58; 95% CI 0.35-0.93) reduced risk of CVD, respectively. Conclusion: Higher HSS are associated with a lower risk of CVD events in the community people with T2D.