Nonlinear HbA1c thresholds reveal accelerated atherogenic remodeling and improved risk reclassification in type 2 diabetes
Abstract
Dysglycemia, lipid metabolism, and cardiovascular disease (CVD) progression in type 2 diabetes (T2D) are closely interconnected, yet the non-linear lipid remodeling processes underlying atherogenic dyslipidemia remain insufficiently defined. This study aimed to identify HbA1c thresholds associated with accelerated lipid-driven atherogenesis, quantify the mediating role of the triglyceride-to-HDL cholesterol ratio (TG/HDL-C)—a surrogate of insulin-resistance–related lipid metabolism—and assess the incremental predictive value of the Atherogenic Index of Plasma (AIP) within the clinically ambiguous “glycemic gray zone.” A total of 271 adults with T2D not receiving lipid-lowering therapy were retrospectively grouped by HbA1c: good (
Fields of Study & Subjects
Diabetes
Cardiovascular Risks
and Lipoproteins
Cardiovascular Function and Risk Factors
Lipoproteins and Cardiovascular Health
Publication details
- Journal / source
- Frontiers in Cardiovascular Medicine
- Publisher
- Frontiers Media SA
- Volume
- 13
- Pages
- 1751404–1751404
- Publication date
- 30 January 2026
- Language
- EN