Congestion, but not low cardiac output, is independently associated with acute kidney injury following contrast agent exposure
Abstract
Aim Contrast-associated acute kidney injury (CA-AKI) is frequently associated with adverse outcomes. Renal perfusion gradient is central to glomerular filtration. While renal vasoconstriction can partially compensate low-output-associated impairment of the renal perfusion gradient, venous congestion cannot be compensated. We hypothesized that congestion is a stronger predictor of CA-AKI than low output in cardiovascular diseases. Methods and results An all-comer single-center cohort of 3,126 cases undergoing coronary angiography with simultaneous right heart catheterization was analyzed. Patients were divided into four categories: congested [right atrial pressure (RAP) >10 mmHg and cardiac index (CI) >=2.2 L/min/m 2 ], low output (RAP
Fields of Study & Subjects
Acute Kidney Injury Research
Chronic Kidney Disease and Diabetes
Dialysis and Renal Disease Management
Publication details
- Journal / source
- Frontiers in Cardiovascular Medicine
- Publisher
- Frontiers Media SA
- Volume
- 13
- Pages
- 1797135–1797135
- Publication date
- 15 June 2026
- Language
- EN