Association of metabolic dysfunction-associated steatotic liver disease with bone health in adults: a systematic review and meta-analysis of observational studies
Abstract
Background: Several studies have explored the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on bone mineral density (BMD) and bone turnover markers (BTMs) in adults and the risk of osteoporotic fractures. However, the extent of adverse effects of MASLD on bone health remains uncertain. This systematic review and meta-analysis aimed to investigate the effects of MASLD on bone health in adults. Methods: We searched PubMed, Medline, EMBASE, Cochrane Library, and Scopus for observational studies published from inception to June 2025 that reported MASLD effects on bone health. Results: , 95% CI: 0.01 to 0.06, P = 0.002). MASLD was also significantly associated with increased osteoporosis/osteoporotic fractures (OR: 1.23, 95% CI: 1.13-1.34; P
Fields of Study & Subjects
Liver Disease Diagnosis and Treatment
Bone health and osteoporosis research
Parathyroid Disorders and Treatments
Publication details
- Journal / source
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Volume
- 16
- Pages
- 1717852–1717852
- Publication date
- 12 January 2026
- Language
- EN