TyG index and MAFLD severity are associated with subclinical LV dysfunction in T2DM patients: a cross−sectional study

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent in type 2 diabetes mellitus (T2DM) and may contribute to early myocardial dysfunction. The Fibrosis-4 (Fib-4) index is a reliable marker of hepatic fibrosis, and the triglyceride-glucose (TyG) index is an effective indicator of insulin resistance (IR). Both are linked to various cardiovascular diseases (CVDs).However, their combined impact on subclinical left ventricular dysfunction (SLVD) remains unclear. This study aimed to explore the associations between hepatic fibrosis, IR, and SLVD in T2DM patients. Methods: We enrolled 270 T2DM patients between September 2024 and April 2025.MAFLD was diagnosed by ultrasonography, hepatic fibrosis was assessed using the Fib-4 index, and insulin resistance was estimated using the TyG index formula. Left Ventricular Global Longitudinal Strain (LV GLS) was measured by speckle-tracking echocardiography, with SLVD defined as absolute value of LV GLS