Successful ovulation and pregnancy with pulsatile GnRH pump therapy in a polycystic ovary syndrome (PCOS) patient: a case report

Polycystic ovary syndrome (PCOS) is one of the main causes of anovulatory infertility in women of reproductive age. The main ovulation induction protocols currently used in clinical practice primarily include letrozole, clomiphene, and gonadotropins. However, some patients may exhibit drug resistance or experience ovarian hyperstimulation syndrome (OHSS). In this article, we report a case of a 28-year-old patient with PCOS who had a normal body mass index (BMI) and normal level of luteinizing hormone (LH), failed to conceive with letrozole combined with human menopausal gonadotropin (HMG) but achieved successful ovulation and pregnancy with pulsatile gonadotropin-releasing hormone (GnRH) pump therapy, without OHSS or other adverse effects. This case demonstrates the potential efficacy of pulsatile GnRH pump therapy in PCOS patients who have failed to conceive with conventional ovulation induction, suggesting its potential as a promising alternative in clinical management.