Inflammatory markers associated with albuminuria and early atherosclerosis in type 2 diabetic kidney disease: a cross-sectional study

Frontiers in Endocrinology 2026 Open access

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Authors: Ainhoa González-Luis, Orlando Siverio-Morales, Carolina Hernández-Carballo, Carmen Mora-Fernández, Ernesto Martín-Núñez, Andrea Reyes-Carrión, J. Diego Carlos-Monzón, Juan F. Navarro-González, Javier Donate-Correa
DOI: 10.3389/fendo.2026.1732900
Cited by: 1
References: 53

Abstract

Background Albuminuria is a recognized marker of renal injury in diabetic kidney disease (DKD), and growing evidence suggests it may also drive systemic inflammation and atherosclerosis. However, mechanisms linking albuminuria to vascular disease remain unclear. Methods We conducted a cross-sectional study including 362 subjects with type 2 diabetes and moderate chronic kidney disease (CKD) to evaluate the associations between albuminuria, circulating and leukocyte inflammatory markers, and measures of subclinical atherosclerosis (SA). SA was defined by carotid intima-media thickness (CIMT) ≥0.9 mm or ankle-brachial index (ABI)

Fields of Study & Subjects

Cardiovascular Health and Disease Prevention Chronic Kidney Disease and Diabetes Peripheral Artery Disease Management

Publication details

Journal / source
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Volume
17
Pages
1732900–1732900
Publication date
26 February 2026
Language
EN