Genetics and pathophysiology of diffuse idiopathic skeletal hyperostosis

Frontiers in Endocrinology 2026 Open access

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Authors: Wenhao Ji, Wanlei Yang, Shikang Su, Simin Sun, Huanhao Cai, Kangnan Wang, Bin Pan, Yu Qian
DOI: 10.3389/fendo.2026.1745930
Cited by: 1
References: 114

Abstract

Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a systemic condition primarily characterized by flowing ossification along the anterolateral aspects of the spine, often leading to back pain, dysphagia, and an increased risk of spinal fractures. Despite its significant clinical burden and high prevalence among the elderly, DISH remains underdiagnosed and poorly understood, with no disease-modifying therapies currently available. This article provides a comprehensive review of the genetic variations and environmental factors involved in the pathogenesis of DISH, encompassing recent research progress in inflammation, metabolism, pathogenic genes, and animal models. It also critically highlights the current challenges and future directions in DISH research.

Fields of Study & Subjects

Spondyloarthritis Studies and Treatments Osteomyelitis and Bone Disorders Research Heterotopic Ossification and Related Conditions

Publication details

Journal / source
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Volume
17
Pages
1745930–1745930
Publication date
17 February 2026
Language
EN