Prognostic value of the triglyceride–glucose index for ICU mortality in non-diabetic sepsis: a restricted cubic spline analysis

Background: The triglyceride-glucose (TyG) index has been identified as a metabolic marker associated with adverse outcomes in sepsis, but its prognostic value in non-diabetic septic patients remains unclear. Objective: To assess the association between TyG levels and ICU mortality in non-diabetic sepsis and validate the findings in an external cohort. Methods: A retrospective analysis of 2,217 non-diabetic sepsis patients from the MIMIC-IV database was conducted using multivariate logistic regression, threshold effect analysis, restricted cubic spline (RCS) modeling, and subgroup analyses. External validation was performed in an independent ICU cohort of 185 non-diabetic sepsis patients from The Central Hospital of Enshi, stratified by the MIMIC-derived TyG cut-off of 9.163. Results: ICU mortality in the MIMIC cohort was 12.2%. Compared with Q2, Q4 showed a significantly increased mortality risk (OR = 1.49, 95% CI: 1.12-1.97, P = 0.006). RCS analysis demonstrated a significant U-shaped association with a threshold at TyG = 9.163. Subgroup analyses confirmed consistent trends. In the external validation cohort, mortality was higher in the high-TyG group than in the low-TyG group (29.0% vs. 21.7%), showing a directionally consistent, though non-significant, trend (P = 0.23). Conclusion: The TyG index is independently associated with ICU mortality in non-diabetic sepsis and exhibits a clear U-shaped pattern. The external validation cohort demonstrated a similar risk trend, supporting the broader applicability of TyG as a simple metabolic marker for risk stratification.