Impact of TyG index on coronary plaques in patients with coronary artery disease under aggressive lipid-lowering therapy

Background One of residual risks of coronary artery disease (CAD) occurrence and coronary plaque progression might be a triglyceride-glucose index (TyG index). Thus, this study aimed to investigate the impact of TyG index on coronary artery plaques detected by serial intravascular ultrasound (IVUS) in patients with CAD under low-density lipoprotein cholesterol (LDL-C) lowering therapy represented by statins. Methods This observational cohort study included three clinical prospective trials (the ENTERPRISE trial, ESPECIAL-ACS study, and ZEUS trial) in which coronary plaques were assessed using serial grayscale IVUS at baseline and at 6–12 months follow-up. The patients were divided into two groups according to the cutoff value of baseline TyG index (dichotomized to ≥ or