Association of high sensitivity C-reactive protein-triglyceride glucose index and chronic kidney disease: a cross-sectional study

Background Chronic kidney disease (CKD) represents a significant global health burden. Its pathogenesis is closely linked to a state of metabolic inflammation, involving insulin resistance and chronic low-grade inflammation. The high-sensitivity C-reactive protein-triglyceride glucose index (CTI) is a novel composite biomarker integrating inflammatory and metabolic information, yet its association with CKD in the general population remains unclear. Objective This study aimed to investigate the cross-sectional association between the CTI and the prevalence of CKD in a health examination population. Methods A total of 10–287 adults who underwent routine health check-ups were included. The CTI was calculated as the product of high-sensitivity C-reactive protein (hs-CRP) and the triglyceride-glucose (TyG) index. CKD was defined as an estimated glomerular filtration rate (eGFR)