Vitamin D and cardiovascular autonomic neuropathy in type 2 diabetes mellitus according to diabetic kidney disease stage

Frontiers in Endocrinology 2026 Open access

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Authors: João Felício, Ester Chambouleyron, Valéria Nascimento, Isabel Fernandes, Lícia Ruivo, Maria Vitória Hupp, Lilian Silva, Natércia de Queiroz, Franciane de Melo, Ana Carolina de Souza, Márcia dos Santos, LORENA DE MORAES
+10 more Mayana Barros, Danielle Pinheiro, Maria Eduarda do Carmo; Universidade Estadual do Ceará – Moura, Beatriz Lobo, Pedro Piani, Ana Regina Motta, Melissa dos Reis, Valéria Suênya Leal, Priscila de Figueiredo, Karem Felício
DOI: 10.3389/fendo.2026.1810159
Cited by: 1
References: 62

Abstract

Background/objectives: Cardiovascular autonomic neuropathy (CAN) may be associated with other diabetes mellitus-related complications. In addition, lower vitamin D (VD) levels have been associated with diabetic kidney disease (DKD) and diabetic neuropathy. We evaluated the relationship between serum VD and CAN in patients with type 2 Diabetes Mellitus (T2DM) in early and advanced stages of DKD. Methods: Seventy-six T2DM patients, 28 in early DKD stage (urine albumin to creatinine ratio (UACR)): 30 to 299 mg/g - group 1), and 48 in advanced DKD stage (UACR ≥300 mg/g - group 2), participated. Results: In group 1, prevalence of CAN was 46% versus 75% in group 2 (p=0.01). 25(OH)D was lower in group 2 (26.3 ± 9.8 vs 30.0 ± 8.0; p

Fields of Study & Subjects

Vitamin D Research Studies Heart Rate Variability and Autonomic Control Cardiovascular Disease and Adiposity

Publication details

Journal / source
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Volume
17
Pages
1810159–1810159
Publication date
15 April 2026
Language
EN