Advancing human ovarian biology in tandem with clinical care: considerations for collecting ovarian tissue for research after oophorectomy for tissue cryopreservation

Frontiers in Endocrinology 2026 Open access

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Authors: Margaret Brunette, Karen Burns, Holly R. Hoefgen, Shuo Xiao, Francesca E. Duncan, Monica M. Laronda, Ariella Shikanov, Mary Zelinski, Veronica Gomez-Lobo
DOI: 10.3389/fendo.2026.1866925
Cited by: 1
References: 43

Abstract

Increased access to OTC has enabled the collection, with patient consent, of research tissue samples from healthy premenopausal patients. These samples are a critical resource to advance our understanding of fundamental ovarian biology. When choosing a preservation method for the tissue collected for research purposes, it is important to define what outcomes are desired from tissue analysis. If tissue is preserved in certain ways the types of analyses available will be limited. This review details various processing methods that can be undertaken in the operating room, or after transportation, and examples of experimental approaches that are applicable to ovarian tissue research.

Fields of Study & Subjects

Reproductive Biology and Fertility Ovarian function and disorders Reproductive Health and Technologies

Publication details

Journal / source
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Volume
17
Pages
1866925–1866925
Publication date
3 June 2026
Language
EN