Cuproptosis-driven reprogramming of fibroblast communication by GK is associated with the immune microenvironment in diabetic foot ulcers
Abstract
Background Diabetic foot ulcers (DFUs) involve chronic inflammation and impaired healing. Emerging evidence implicates copper-dependent regulated cell death (cuproptosis) in immune microenvironment regulation, but its role in DFU fibroblast-immune crosstalk remains unknown. Methods We analyzed scRNA-seq datasets (GSE231643, GSE134431) from DFU/healthy skin. After quality control (25,198 cells retained) and clustering, fibroblasts with elevated cuproptosis scores were identified via ssGSEA. Fibroblast-specific DEGs were screened (Wilcoxon rank-sum; |log 2 FC|>1, p
Fields of Study & Subjects
Diabetic Foot Ulcer Assessment and Management
Wound Healing and Treatments
Mesenchymal stem cell research
Publication details
- Journal / source
- Frontiers in Immunology
- Volume
- 16
- Pages
- 1687806–1687806
- Publication date
- 9 January 2026
- Language
- EN