Gut microbiota and postoperative complications in colorectal surgery and its potential association with intestinal permeability and NLRP6 inflammasome

Frontiers in Immunology 2026 Open access

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Authors: Manuel Buitrago-Ruiz, Celia Arias-Sánchez, Maria Magdalena Asensio-López, Juan José Martínez-García, Victoriano Soria-Aledo, Graciela Valero-Navarro, Santiago Cuevas
DOI: 10.3389/fimmu.2025.1701650
Cited by: 1
References: 92

Abstract

This manuscript reviews the current evidence describing the relationships between surgical trauma, altered intestinal permeability, dysbiosis, inflammasome activation, and postoperative inflammation in the development of AL. Surgical tissue disruption and anastomosis creation can modify the intestinal microbiota and compromise epithelial barrier function, promoting a proinflammatory environment mediated by inflammasomes such as NLRP3, NLRC4, and NLRP6. This review analyses the inflammatory pathways that may regulate intestinal homeostasis, their potential contribution to postoperative complications such as AL, and how these insights may guide future preventive strategies or help identify patients at increased risk.

Fields of Study & Subjects

Gut microbiota and health Enhanced Recovery After Surgery Colorectal Cancer Surgical Treatments

Publication details

Journal / source
Frontiers in Immunology
Publisher
Frontiers Media SA
Volume
16
Pages
1701650–1701650
Publication date
26 January 2026
Language
EN