Dissecting the role of KLF5: from tumor progression to immune interactions with emphasis on glioma and bladder cancer

Background: Krüppel-like factor 5 (KLF5) is involved in various aspects of tumor development, metastasis, and drug resistance through their regulation of transcription and translation, yet its functions in a comprehensive cancer framework are still unclear. Methods: Our research involved a detailed pan-cancer analysis using multi-omics data sourced from various public databases. We investigated the clinical characteristics, prognostic significance, mutations, and methylation patterns of KLF5 across various cancer types. Results: We discovered that KLF5 is implicated in tumor progression and are prognostic markers across pan-cancer. KLF5 is significantly linked to various malignant pathways across different types of cancer. Additionally, KLF5 has associations with several immune-related features. Ultimately, experiments were carried out to investigate whether KLF5 could serve as a promising indicator for glioma and bladder cancer. Conclusion: KLF5 may be utilized as a diagnostic tool for cancer, a predictor of its progression, and a guide for treatment., with particular promise as a therapeutic target for glioma and bladder cancer.