Hashimoto’s thyroiditis is associated with reduced invasiveness in papillary thyroid carcinoma: a propensity score-matched retrospective cohort study

Background: Papillary thyroid cancer (PTC), the predominant histologic subtype of thyroid cancer cases, has increased substantially over the past decades. In previous studies, Hashimoto's thyroiditis (HT) exerts a paradoxical dual role in PTC. However, limited studies have specifically examined the association between HT and the invasion of PTC. Methods: In this retrospective study, 10329 PTC patients were selected, and the clinicopathological features were retrospectively analyzed. Propensity score matching (PSM) was employed to minimize confounding effects from baseline variables. Univariate analysis and multivariate analysis were performed using binary logistic regression to determine the predictive factor. Odds ratio (OR) and 95% confidence interval (CI) were calculated. Results: Among 10329 PTC patients, 992 (9.6%) individuals were diagnosed with HT. Compared to the non-HT group, the HT group demonstrated lower rates of extrathyroidal extension (p