Leishmania mediated regulation of host metabolism: impact on host immunity

Frontiers in Immunology 2026 Open access

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Authors: Somtochukwu S. Onwah, Gaurav Gupta, Romaniya Zayats, Amol Singh Banga, Kashish Chhotaria, Gurtej Ahluwalia, Jude E. Uzonna
DOI: 10.3389/fimmu.2026.1750304
Cited by: 3
References: 221

Abstract

Leishmaniasis, a vector-borne disease affecting millions worldwide, is caused by protozoan parasite Leishmania . In mammalian hosts, Leishmania survives in the hostile environment of macrophages by exploiting key metabolic pathways to evade their destruction and subvert the host immune responses. Understanding of how Leishmania alters host immune cell metabolism could reveal novel targets for vaccines and therapeutics for effective control of Leishmaniasis. This review focuses on Leishmania -induced modulation of host immune response, with particular focus on reprograming of key metabolic pathways in macrophages, dendritic cells, T cells and other immune cells.

Fields of Study & Subjects

Research on Leishmaniasis Studies Macrophage Migration Inhibitory Factor Trypanosoma species research and implications

Publication details

Journal / source
Frontiers in Immunology
Publisher
Frontiers Media SA
Volume
17
Pages
1750304–1750304
Publication date
18 February 2026
Language
EN