Effects of aging on host responses in gingival crevicular fluid in natural gingivitis

Aim: This study compared host responses against natural gingivitis in the gingival crevicular fluid (GCF) in young and aged periodontium. Materials and methods: This cross-sectional study recruited two patient populations with natural gingivitis in young (18-35 years old) and elder cohorts (36-75 years old). GCF samples were analyzed for 39 inflammatory and tissue remodeling mediators using bead-based multiplex immunoassays. Independent t-tests with false discovery rate adjustments were used to compare mediator expressions between groups. Results: Forty patients were enrolled in these comparisons, including young patients (n=22) and elder patients (n=18). In comparison with the young group, the elder group had greater clinical attachment loss and higher expression of MPO (p