The guardian of the genome meets immunotherapy: p53-based strategies
Abstract
Originally reported as an oncogene and currently known to be a major "genome guardian", the p53 protein remains one of the most explored transcription factors, exhibiting variety of functions both within transcription regulation and beyond. Given that p53 dysfunction contributes to the majority of human cancers, understanding its regulatory mechanisms and therapeutic potential remains a primary research focus. This review addresses the key aspects of p53 regulation and functionality, analyses its role in tumor evolution, and provides a comprehensive analysis of current and emerging therapeutic strategies targeting the p53, with particular emphasis on immunotherapy approaches.
Fields of Study & Subjects
Cancer-related Molecular Pathways
Hedgehog Signaling Pathway Studies
Protein Degradation and Inhibitors
Publication details
- Journal / source
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Volume
- 17
- Pages
- 1762679–1762679
- Publication date
- 10 March 2026
- Language
- EN