Chrono-immunotherapy’s current and future optimization strategies: immunotherapy timing in line with the circadian rhythm brings longer survival benefits
Abstract
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for malignant tumors such as advanced lung cancer, but their efficacy is limited. In recent years, the circadian rhythm has provided a brand-new optimization strategy for immunotherapy. This perspective article aims to explore the potential mechanisms of the interaction between immunotherapy and circadian rhythms, reviews clinical evidence supporting that "time-of-day receipt of ICIs brings better therapeutic effects", and conduct an in-depth analysis of the current practical challenges of chrono-immunotherapy. And emphasize the potential of "chrono-immunotherapy" as a valuable therapeutic approach.
Fields of Study & Subjects
Circadian rhythm and melatonin
Cancer Immunotherapy and Biomarkers
Dietary Effects on Health
Publication details
- Journal / source
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Volume
- 17
- Pages
- 1777437–1777437
- Publication date
- 16 February 2026
- Language
- EN