Editorial: Metabolism in the tumour microenvironment: implications for pathogenesis and therapeutics

The tumour microenvironment (TME) is a heterogeneous composition of stromal, immune 32 cells that respond to local and systemic cues and influence tumour progression and ( de Visser 33 and Joyce, 2023). Preclinical and clinical evidence demonstrate a strong reciprocal relationship between 34 tumour cell oncogenesis and its TME (Klemm and Joyce, 2015). Rather than serving as a passive backdrop, 35the TME functions as a metabolic ecosystem that shapes immunosurveillance, immune evasion and 36 responsiveness to therapy (Zou and Green, 2023). Importantly, the articles featured in this Research Topic 37 converge on a shared principle that metabolic rewiring of the TME is an active driver of immune 38 dysfunction which drives tumour growth and metastasis and contributes to the global health burden of 39 cancer. 40We curated 11 articles that highlight this rapidly advancing frontier, focused on how metabolism reshapes 41 the TME. Collectively, these contributions synthesize mechanistic advances, discuss translational hurdles 42 and outline opportunities for therapeutic advancement that leverage these findings in clinical practice.