The role of ALOX15 in inflammation-related diseases

Arachidonate 15-lipoxygenase (ALOX15) is a key member of the lipoxygenase family, catalyzing the oxidation of polyunsaturated fatty acids (PUFAs) to produce numerous biologically active lipid mediators. Recent studies have revealed that ALOX15 and its metabolites play a complex regulatory role in inflammatory responses. They are not only involved in inflammation resolution through the production of pro-resolving mediators but can also generate pro-inflammatory lipid signals that exacerbate inflammatory damage. Research utilizing gene knockout and transgenic animal models further indicates that ALOX15 contributes to the pathogenesis of various inflammation-related diseases, including neuroinflammation, atherosclerosis, asthma, rheumatoid arthritis, and metabolic inflammatory diseases. This article systematically reviews the current understanding of the role of ALOX15 in inflammation-associated diseases.