Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms
Abstract
Neurodegenerative diseases are a group of chronic, progressive neurological disorders caused by the degeneration and functional loss of neurons and glial cells, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD). Although numerous treatments are available for these diseases, therapeutic outcomes remain unsatisfactory because of their poorly understood pathogeneses of these diseases. Vagus nerve stimulation (VNS), a noninvasive or minimally invasive neuromodulation technique, has shown significant potential in mitigating neurodegenerative conditions. This review explores the mechanisms of action and clinical applications of VNS in neurodegenerative diseases, providing novel insights for the development of novel treatments.
Fields of Study & Subjects
Vagus Nerve Stimulation Research
Neurological disorders and treatments
Botulinum Toxin and Related Neurological Disorders
Publication details
- Journal / source
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Volume
- 17
- Pages
- 1811107–1811107
- Publication date
- 23 March 2026
- Language
- EN