Vitamin D deficiency and pregnancy outcomes: LC-MS/MS-based evaluation in Southwest China
Abstract
Background Vitamin D insufficiency is a global public health concern, particularly among Chinese pregnant women, yet southwest-China data using gold-standard LC-MS/MS are scarce. Methods A retrospective cohort study was conducted on 2,742 pregnancies delivered in Deyang. Serum 25(OH)D2 and 25(OH)D3 quantified by LC-MS/MS (CV < 7%). Univariate and multivariate logistic regression analyses were used to identify risk factors for vitamin D deficiency and assess its associations with pregnancy outcomes. Efficacy of vitamin D supplementation was also compared. Results The median serum 25(OH)D concentration was 16.3 ng/ml, with 62.5% of participants classified as vitamin D deficient (
Fields of Study & Subjects
Vitamin D Research Studies
Biotin and Related Studies
Per- and polyfluoroalkyl substances research
Publication details
- Journal / source
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Volume
- 12
- Pages
- 1711506–1711506
- Publication date
- 22 January 2026
- Language
- EN