Synergistic eradication of Candida albicans prosthetic valve endocarditis with liposomal amphotericin B and high-dose caspofungin: a case report
Abstract
was diagnosed in a 58-year-old woman 1 year after mitral bioprosthetic replacement for severe regurgitation. The diagnosis was prompted by recurrent fever and confirmed by positive blood cultures and echocardiographic vegetations. The isolate was susceptible to amphotericin B, azoles, and echinocandins. Despite meeting surgical criteria, the patient declined reoperation. Salvage therapy with liposomal amphotericin B combined with high-dose caspofungin successfully resolved symptoms and led to vegetation regression on follow-up imaging. The patient was discharged on lifelong suppressive antifungal therapy based on susceptibility profiling.
Fields of Study & Subjects
Infective Endocarditis Diagnosis and Management
Antifungal resistance and susceptibility
Cardiac Valve Diseases and Treatments
Publication details
- Journal / source
- Frontiers in Medicine
- Volume
- 13
- Pages
- 1704496–1704496
- Publication date
- 4 March 2026
- Language
- EN