The key role and research progress of endothelial cells in renal microcirculation

Background: Microcirculation disorder is the main reason for the occurrence and development of kidney diseases. Studies have shown that endothelial cells play an important role in renal microcirculation disorders. To clarify the specific function of endothelial cells on renal microcirculation and its effect after damage, and to evaluate the existing research. Methods: The reliable articles included in CNKI, PubMed, Central, Scopus, and Web of Science databases were selected as the research objects. Peer-reviewed articles and reports on endothelial cells and renal microcirculation disorders were retrieved with a literature period of nearly 15 years. Results and conclusions: We found that endothelial cells regulate the relaxation of renal microvessels, maintain the balance of microvascular perfusion and function stability, and analyze the effect of endothelial cell dysfunction on renal microcirculation, as well as the changes of endothelial cells in a variety of renal diseases, aiming to provide theoretical basis and new research direction for the prevention and treatment of renal related diseases.