Increase in serum prolactin levels as a potential biomarker in Crohn’s disease: a prospective cohort study

Frontiers in Medicine 2026 Open access

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Authors: Mengjie Lu, Minmin Xu, Xinyi Tang, Lichao Qiao, Hongjin Chen, Bolin Yang
DOI: 10.3389/fmed.2026.1737904
Cited by: 2
References: 40

Abstract

Background: Crohn's disease (CD) management lacks biomarkers that precisely reflect immune activity. Prolactin (PRL) has immunomodulatory functions, but its role in CD is unclear. Aim: To investigate serum PRL changes in CD patients and evaluate its potential as a biomarker for disease activity and treatment response. Methods: In a prospective cohort study, serum PRL levels were analyzed in 185 CD patients and 58 healthy controls, and correlated with clinical markers (CRP, FC). Results: Serum PRL levels were significantly higher in CD patients versus controls (p

Fields of Study & Subjects

Growth Hormone and Insulin-like Growth Factors Inflammatory Bowel Disease Hypothalamic control of reproductive hormones

Publication details

Journal / source
Frontiers in Medicine
Publisher
Frontiers Media SA
Volume
13
Pages
1737904–1737904
Publication date
19 January 2026
Language
EN